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Total 409719 results found since Jan 2013.

Vascular calcification : from pathophysiology to biomarkers.
Abstract The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlighted more and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtelly identified as predisposing factors. But even if the process is better understood, many questions still remain unanswered. This review briefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, ...
Source: International Journal of Clinical Chemistry - September 15, 2014 Category: Chemistry Authors: Evrard S, Delanaye P, Kamel S, Cristol JP, Cavalier E, SFBC/SN joined working group on vascular calcifications, SFBC/SN joined working group on vascular calcifications Tags: Clin Chim Acta Source Type: research

Inflammatory Molecular Mediators and Pathways Involved in Vascular Aging and Stroke: A Comprehensive Review
Curr Med Chem. 2021 Sep 1. doi: 10.2174/0929867328666210901122359. Online ahead of print.ABSTRACTThere is an increase in the incidence of cardiovascular diseases with aging and it is one of the leading causes of death worldwide. The main cardiovascular pathologies include atherosclerosis, stroke, myocardial infarction, hypertension and stroke. Chronic inflammation is one of the significant contributors to the age-related vascular diseases. Therefore, it is important to understand the molecular mechanisms of the persistent inflammatory conditions occurring in the blood vessels as well as the signaling pathways involved. Her...
Source: Current Medicinal Chemistry - September 7, 2021 Category: Chemistry Authors: Amro M Soliman Srijit Das Pasuk Mahakkanukrauh Source Type: research

The ERM complex: a new player involved in diabetes-induced vascular leakage.
In conclusion, ERMs play an essential role in endothelium homeostasis and can be envisaged as a new therapeutic molecular target for preventing or arresting diabetes-induced vascular leakage. PMID: 30332939 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - October 16, 2018 Category: Chemistry Authors: Simo-Servat O, Hernández C, Simó R Tags: Curr Med Chem Source Type: research

L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes.
Abstract Vascular complications are among the most serious manifestations of diabetes. Atherosclerosis is the main cause of reduced life quality and expectancy in diabetics, whereas diabetic nephropathy and retinopathy are the most common causes of end-stage renal disease and blindness. An effective therapeutic approach to prevent vascular complications should counteract the mechanisms of injury. Among them, the toxic effects of advanced glycation (AGEs) and lipoxidation (ALEs) end-products are well-recognized contributors to these sequelae. L-carnosine (β-alanyl-L-histidine) acts as a quencher of the AGE/ALE pre...
Source: Current Medicinal Chemistry - July 9, 2019 Category: Chemistry Authors: Menini S, Iacobini C, Fantauzzi CB, Pugliese G Tags: Curr Med Chem Source Type: research

Molecules, Vol. 24, Pages 1182: A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity
This study aims to bring together information on the phenolic compounds present in the bark of woody vascular plants by discussing extraction methods, the chemical composition of the extracts and potential biological effects. The literature data used in this paper were collected via PubMed (2004–2019). Search terms were: bark, rhytidome, woody vascular plant, polyphenols, phenolic compounds, biologic activity, antioxidant, immunostimulatory, antimutagenic, antibacterial, anti-inflammatory, and antitumoral. This paper intends to highlight the fact that the polyphenolic extracts obtained from the bark of woody vascular pla...
Source: Molecules - March 25, 2019 Category: Chemistry Authors: Corneliu Tanase Sanda Co șarcă Daniela-Lucia Muntean Tags: Review Source Type: research

INFERYS Rescoring: boosting peptide identifications and scoring confidence of database search results
Rapid Commun Mass Spectrom. 2021 May 20:e9128. doi: 10.1002/rcm.9128. Online ahead of print.ABSTRACTDatabase search engines for bottom-up proteomics largely ignore peptide fragment ion intensities during the automated scoring of tandem mass spectra against protein databases. Recent advances in deep learning allow the accurate prediction of peptide fragment ion intensities. Using these predictions to calculate additional intensity-based scores help to overcome this drawback. Here, we describe a processing workflow termed INFERYS™ Rescoring for the intensity-based rescoring of Sequest HT search engine results in Thermo Sci...
Source: Rapid Communications in Mass Spectrometry : RCM - May 20, 2021 Category: Chemistry Authors: Daniel P Zolg Siegfried Gessulat Carmen Paschke Michael Graber Magnus Rathke-Kuhnert Florian Seefried Kai Fitzemeier Frank Berg Daniel Lopez-Ferrer David Horn Christoph Henrich Andreas Huhmer Bernard Delanghe Martin Frejno Source Type: research

Prediction of vascular injury by cavitation microbubbles in a focused ultrasound field
Ultrason Sonochem. 2022 Jul 26;88:106103. doi: 10.1016/j.ultsonch.2022.106103. Online ahead of print.ABSTRACTMany studies have shown that microbubble cavitation is one mechanism for vascular injury under ultrasonic excitation. Previous work has attributed vascular damage to vessel expansions and invaginations due to the expansion and contraction of microbubbles. However, the mechanisms of vascular damage are not fully understood. In this paper, we investigate, theoretically and experimentally, the vessel injury due to stress induced by ultrasound-induced cavitation (UIC). A bubble-fluid-vessel coupling model is constructed...
Source: Ultrasonics Sonochemistry - July 31, 2022 Category: Chemistry Authors: Yaqian Xie Jiwen Hu Weirui Lei Shengyou Qian Source Type: research